During premenstrual days, 30 to 40% of all women regularly experience psychological and physical discomfort. These disappear with the onset of menstruation. The causes of premenstrual syndrome (PMS) are still unknown. Several theories suggest an increased sensitivity to the hormone fluctuations that occur during a cycle. This could also impair the transmission of stimuli in the nervous system. PMS is typically characterized by physical changes, a negative mood, and irritability as well as exhaustion,mental overload, and reduced productivity.
Micronutrients have a proven influence on hormones, the nervous system, and the psyche. Vitamin B6 is regulates hormone activity, magnesium supports the nerve function, iron reduces fatigue and exhaustion, and zinc helps maintain cognitive functions. The aim of this study was to find out whether the threemonth use of a combination product with micronutrients and plant extracts (Nutrifem PMS Formula**) leads to a lower intensity of premenstrual discomfort and thus stabilizes mood, emotions, performance, and well-being. The intensity of the discomfort was assessed at the beginning and end of the study using a scale (numerical rating scale, NRS) on which the participants were able to assess the intensity of their discomfort from 0 (no intensity) to 10 (strongest intensity imaginable). Mood and performance were assessed, among other things. A WHO-5 questionnaire was used to survey quality of life and well-being. In total, the data of 68 participants aged 20 to 50 years was evaluated.
**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.